Calculate the mass, volume or concentration required for a solution. Structure, properties, spectra, suppliers and links for: Cinnamic acid, phenyl ester, 2757-04-2. It is obtained from oil of cinnamon, or from balsams such as storax. This acid and its hydroxylated derivatives have also been reported to have antifungal activity [70], preventing fungal spore germination and antityrosinase enzyme activity with potential skin-whitening activity [71]. Puromycin 2HCl is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor. The solubilities of three cinnamic acid esters, namely, methyl ferulate, methyl p -coumarate, and methyl sinapate, in eight imidazolium-based ionic liquids composed of the PF 6− and BF 4− anions have been measured at (30, 39, and 48) °C. Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. - Find MSDS or SDS, a COA, data sheets and more information. It exists as both a cis and a trans isomer, although the latter is more common. Cyclosporin A (Cyclosporine A) is an immunosuppressive agent, binds to the cyclophilin and then inhibits calcineurin with IC50 of 7 nM in a cell-free assay, widely used in organ transplantation to prevent rejection. The color of the native bilberry anthocyanin solution dissolved in ethyl acetate and dioxane was transparent. In der Pflanze entsteht die Sinapinsäure als ein Produkt der Zimtsäurebiosynthese. It is found in Cinnamomum cassia. Cinnamic acid is an organic compound with the formula C 6 H 5 CHCHCO 2 H. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Outside of the human body, cinnamic acid has been detected, but not quantified in, chinese cinnamons. The experiments were taken at 308.2, 318.2 and 328.2 K. The pressure range was from 11 to 24 MPa. It is collected from the oil of cinnamon and is also found in shea butter. Chemical Properties Cinnamic acid is almost odorless with a burning taste, and … To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'. CONCLUSION . mg/mL， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. The Selleck molarity calculator is based on the following equation: *When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages). * When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online). An-Ci4 presented the highest AD value (6.61%), and An-Ci3 exhibited the lowest TAC value (50.16 mg/g). In this short piece of article, we shall be discussing more about the cinnamic acid The use of natural antimicrobial compounds, such as cinnamic acid and its phenolic derivatives, may help prevent survival of Escherichia coli O157:H7 and other pathogenic bacteria in foods. Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Tip: Chemical formula is case sensitive. Jump to main content Jump to site nav. Treatment with GKT137831 suppresses reactive oxygen species (ROS) production. It is a crystalline compound that is white in colour and is slightly soluble in water. Ausgehend von de… DMSO master liquid, next addμL PEG300， mix and clarify, next addμL * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. EC Number 205-398-1. Recommendation for cinnamic acid usage levels up to: 2.0000 % in the fragrance concentrate. The solid solubilities of cinnamic acid, phenoxyacetic acid and 4-methoxyphenylacetic acid in supercritical carbon dioxide were measured using a semi-flow apparatus. expression of Bcl-2 (a marker of cell proliferation) is reduced, and apoptosis is induced by Cinnamic acid[2]. Cinnamic acid is a polyphenol and an antioxidant. © Copyright 2013 Selleck Chemicals. Catalog No.S3677 After acylating with lipophilic cinnamic acids, the lipid solubility of acylated bilberry anthocyanins significantly improved. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants.It exists as both a cis and a trans isomer, although the latter is more common. In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Synonyms: trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid is also a kind of self-inhibitor produced by fungal spore to prevent germination. The solubilities of three cinnamic acid esters, namely, methyl ferulate, methyl p-coumarate, and methyl sinapate, have been measured in tert-butanol, tert-pentanol, ethyl acetate, and n-hexane, at the temperature range of (303.15 to 321.15) K. It is shown that tert-pentanol is the best solvent for methyl p-coumarate and methyl ferulate and ethyl acetate for methyl sinapate, while the nonpolar n-hexane is … 16 / 106. drug pre-dissolved in μL DMSO (Master liquid concentration Telaglenastat (CB-839) is a potent, selective, and orally bioavailable glutaminase inhibitor with IC50 of 24 nM for recombinant human GAC. It is a member of styrenes and a member of cinnamic acids. 10.5 g of Benzaldehyde shall yield Cinnamic Acid = 148. It is a conjugate acid of a cinnamate. 2.Be sure to add the solvent(s) in order. You can also browse global suppliers,vendor,prices,Price,manufacturers of trans-Cinnamic acid(140-10-3). Is cinnamic acid polar or nonpolar? [1] Niero EL, et al. TLC and 1H NMR analysis confirm the purity of final product, without any cinnamic acid contamination, and thus it is not necessary to make any recrystallization. Cinnamic acid shows genotoxic potential at both tested concentrations, inducing the formation of micronucleated cells[1]. ChEBI Ontology Outgoing trans-cinnamic acid (CHEBI:35697) has role plant metabolite (CHEBI:76924) trans-cinnamic acid (CHEBI:35697) is a cinnamic acid (CHEBI:27386) trans-cinnamic acid (CHEBI:35697) is conjugate acid of trans-cinnamate (CHEBI:15669) Products are for research use only. Ganciclovir (RS-21592, BW-759) is an antiviral drug for feline herpesvirus type-1 with IC50 of 5.2 μM in a cell-free assay. Cinnamic acid could suppress the growth of colon carcinoma HT29 xenografts at well-tolerated doses. 12 x 10. Cinnamic acid is an organic compound with the formula C6H5CHCHCO2H. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Cinnamic acid is a white crystalline acid with a molecular formula C 9 H 8 O 2. Cinnamic acid (Benzenepropenoic acid, Isocinnamic acid, trans-Cinnamic acid, Phenylacrylic acid), a naturally occurring aromatic fatty acid of low toxicity, induces cytostasis and a reversal of malignant properties of human tumor cells in vitro. Ribavirin (NSC-163039, ICN-1229, RTCA, Tribavirin), a synthetic guanosine analogue, possesses a broad spectrum of activity against DNA and RNA viruses. Calcitriol (RO215535, Topitriol) is a nonselective vitamin D receptor activator/agonist(VDRA), exhibiting a 10-fold higher vitamin D receptor (VDR) binding affinity(IC50=0.4 nM) than the selective VDRA paricalcitol. Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations. We report formation of polymorphs and new eutectics and cocrystals of curcumin, a sparingly water-soluble active component in turmeric, structurally similar to cinnamic acid. At last,trans-Cinnamic acid… Cinnamic acid is an organic compound with the formula C 6 H 5 CH=CHCOOH. Cinnamic acid has been reported to exhibit antioxidant and antibacterial activities [63–69]. It is created by the deamination of phenylalanine and it is then itself converted to any of the various polyphenols synthesized by plants. Setanaxib (GKT137831) is a potent, dual NADPH oxidase NOX1/NOX4 inhibitor with Ki of 110 nM and 140 nM, respectively. Linear Formula C 6 H 5 CH=CHCOOH . Method for preparing in vivo formulation：Take μL Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments. Cinnamic acid has the formula C6H5CHCHCOOH and is an odorless white crystalline acid, which is slightly soluble in water. If you have any other enquiries, please leave a message. LB-100 is a water soluble protein phosphatase 2A (PP2A) inhibitor with IC50s of 0.85 μM and 3.87 μM in BxPc-3 and Panc-1 cells. +Add Attachment Instead of HPLC that is a costly and time-consuming method, a chemometric-based approach, net analyte signal standard addition method, was selected for simultaneous determination of CBZ and CIN … (1 u is equal to 1/12 the mass of one atom of carbon-12) In vivo studies indicate that acute lethal doses (LD50) of cinnamic acid is achieved at 160-220 mg/kg (ip) in mice, 2.5 g/kg (oral) in rats and 5 g/kg (dermal) in rabbits. Note：1.Please make sure the liquid is clear before adding the next solvent. Tween 80，mix and clarify, next add μL ddH2O，mix and clarify. All Rights Reserved. Den größten Anteil an Phenolsäuren im Rapssamen macht mit 70 bis 85 % die Sinapinsäure bzw. These are organic aromatic compounds containing a benzene and a carboxylic acid group forming 3-phenylprop-2-enoic acid. 2013, 32:31. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. Phase 1. Thus, cinnamic acid exhibits a low toxicity. eCl@ss 39023931 . The percentage yield of the Cinnamic acid is about 64.8% of melting point 132 °C. Sinapinsäure kommt in der Natur vor allem in Rapssamen vor. ihre Ester aus. It has a role as a plant metabolite. Next day delivery by 10:00 a.m. Order now. Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. The antiproliferative activity of the drug is associated with caspase 9 activation, but not p53 phosphorylation, after 24 h treatment. cis-Cinnamic acid | C9H8O2 | CID 5372954 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. Cinnamic acid has the formula C6H5CHCHCOOH and is an odorless white crystalline acid, which is slightly soluble in water. Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane. MDL number MFCD00004369. (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The username will be used as the login user name and retrieve the password, Copyright 2017 © ChemicalBook. Beilstein/REAXYS Number 1905952 . GKT137831 partly inhibits ferroptosis. Thus, cinnamic acid exhibits a low toxicity, trans-Cinnamic acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid|(E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid, Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment). Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving. Method for preparing DMSO master liquid: ： mg COVID-19 is an emerging, rapidly evolving situation. The original synthesis of … All rights reserved, The mailbox will be used as the login user name and retrieve the password, (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), 2-[3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-methylphenol, LD50 (g/kg): 3.57 orally in rats; >5.0 dermally in rabbits (Letizia), high purity Cinnamic acid kf-wang(at)kf-chem.com, 3-Phenyl-2-propenoic acid (cinnamic acid). Cinnamic acid is freely soluble in benzene, diethyl ether, acetone, and it is insoluble in hexane. Get the latest public health information from CDC: https://www.coronavirus.gov. It has a honey-like odour. Answers to questions you may have can be found in the inhibitor handling instructions. Molecular Weight 148.16 . You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. BAPTA-AM is a selective, membrane-permeable calcium chelator. Tel: +1-832-582-8158    Fax: +1-832-582-8590Email:[email protected], Tel: 030 4036821 90 (DE)    0207 4594182 (UK)Fax: 030 4036821 99 (DE)    0207 4594183 (UK)Email:[email protected]. Cinnamic acid exists in all living organisms, ranging from bacteria to humans. 66 x 100 = 64.8%. This is normal and is due to slight batch-to-batch variations. Mol Med Rep. 2016, 13(5):4159-66. C10H16N2O2 c10h16n2o2. This could make cinnamic acid a potential biomarker for the consumption of these foods. CB-839(Telaglenastat) inudces autophagy and has antitumor activity. Maximised Survey-derived Daily Intakes (MSDI-EU): 28.00 (μg/capita/day) Maximised Survey-derived Daily Intakes (MSDI-USA): 44.00 (μg/capita/day) Structure Class: I: Use levels for FEMA GRAS flavoring substances on which the FEMA Expert Panel based its judgments that the substances … cinnamic acid solubility, Find Quality cinnamic acid solubility and Buy cinnamic acid solubility from Reliable Global cinnamic acid solubility Suppliers from mobile site on m.alibaba.com Not for human use. PubChem Substance ID 24848120 With the CAS number 140-10-3, it is also called trans-Cinnamic Acid, Phenylacrylic acid, Cinnamylic acid, 3-Phenylacrylic acid, (E)-Cinnamic acid, Benzenepropenoic acid, Isocinnamic acid. ). Free Overnight Delivery on orders over $ 500 Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. J Exp Clin Cancer Res. [2] Zhu B, et al. From Wikipedia. B. Erdnuss: 63,6 mg/100 g, Raps: 639,9 mg/100 g). C Classified as an unsaturated carboxylic acid, it occurs naturally in a number of plants. Cinnamic acid is a monocarboxylic acid that consists of acrylic acid bearing a phenyl substituent at the 3-position. CAS 140-10-3, chemical formula C₆H₅CH=CHCOOH. Cinnamic acid is an organic compound with the formula C6H5CH=CHCOOH. Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol. Structure, properties, spectra, suppliers and links for: (E)-4-Methoxycinnamic acid, 30-09-1, 830-09-1, 943-89-5. Cinnamic acid (tCA) upregulates the expression of acetyl‑H3 and acetyl‑H4 proteins in a dose-dependent manner in treated cells and in the tumor tissue of treated mice. DMSO master liquid,next add μL Corn oil，mix and clarify. trans-Cinnamic acid is a weakly acidic compound (based on its pKa). What is Cinnamic acid? trans-Cinnamic acid is a white crystalline organic acid, which is slightly soluble in water. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. 5 / 14. Visit ChemicalBook To find more trans-Cinnamic acid(140-10-3) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. We do not sell to patients. 3.2.7Kovats Retention Index. It is a white crystalline compound that is slightly soluble in water, and freely soluble in many organic solvents. 5 = 14.66 g. Hence, Theoretical yield of Cinnamic Acid = 14.66 g. If reported Practical yield = 9.5 g. Then, Percentage Practical yield = Practical yield / Theoretical yield × 100 = 9. (m3/ug)): Mackay model : 0.00074 Octanol/air (Koa) model: 0.0701 Fraction sorbed to airborne particulates (phi): Junge-Pankow model : 0.026 Mackay model : 0.0559 Octanol/air (Koa) model: 0.849 Atmospheric Oxidation (25 deg C) [AopWin v1.92]: Hydroxyl Radicals Reaction: OVERALL OH Rate Constant = 34.6013 E-12 cm3/molecule-sec Half-Life = 0.309 Days (12-hr day; 1.5E6 OH/cm3) Half-Life … Cinnamic acid is a white crystalline compound with the formula C6H5CH=CHCOOH which is slightly soluble in water, and freely soluble in many organic solvents. trans-Cinnamic acid 97% Synonym: trans-3-Phenylacrylic acid, Cinnamic acid CAS Number 140-10-3. Calculate the dilution required to prepare a stock solution. It exists as trans and cis isomers, but the trans form is the one most often found in nature and is widely used in commerce. Cinnamic acid reduces cell proliferation of glioblastoma, melanoma, prostate and lung carcinoma cells by 50% at concentrations between 1.0 and 4.5 mM. Der Gesamtgehalt von Phenolsäuren in Rapssamenmehl ist deutlich höher als bei anderen Ölpflanzen (z. Cinnamic acid for synthesis. It exists as both a cis and a trans isomer, although the latter is more common. Method for preparing in vivo formulation：Take trans-Cinnamic acid: Description: trans-Cinnamic acid, also known as (e)-cinnamic acid or phenylacrylic acid, belongs to the class of organic compounds known as cinnamic acids. Carbamazepine (CBZ), a nonionizable drug with cinnamic acid (CIN), which is an acidic coformer, was selected to prepare CBZ-CIN cocrystal and its thermodynamic solubility was studied in pH range 2-7. Tags: buy Cinnamic acid | Cinnamic acid supplier | purchase Cinnamic acid | Cinnamic acid cost | Cinnamic acid manufacturer | order Cinnamic acid | Cinnamic acid distributor, In vivo Formulation Calculator (Clear solution), Antineoplastic and Immunosuppressive Antibiotics, Selection Antibiotics for Transfected Cell, FDA-approved & Passed Phase I Drug Library, Human Endogenous Metabolite Compound Library, Anti-Cardiovascular Disease Compound Library, Cytoskeletal Signaling Pathway Compound Library, Endoplasmic Reticulum Stress Compound Library, Exosome Secretion Related Compound Library, Protein-protein Interaction Inhibitor Library, Small Molecule Immuno-Oncology Compound Library. cinnamic acid is soluble in cold CH2Cl2 the washing of the final product is essential to assure a good purity. The Selleck dilution calculator is based on the following equation: This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output ).

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