Hazardous Substances - Art. Details of dossier compliance checks and testing proposal evaluation. EU. Substances undergoing a PBT/vPvB assessment. Page . The ‘Hazard classification’ and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information. 1. of . The ‘Hazard classification and labelling’ section shows the hazards of a substance based on the standardised system of statements and pictograms established under the CLP (Classification Labelling and Packaging) Regulation. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. Other release to the environment of this substance is likely to occur from: indoor use (e.g. InfoCards are generated automatically based on the data available at the time of generation. Danger! UN/NA datasheets display several items from the Hazmat Table: proper shipping names, hazard classes and divisions (explosives may also include a compatibility group letter label codes, and special notes relating to shipping location, shipping name, and whether the material is an inhalation hazard. If available, additional information on classification and labelling (C&L) is derived from REACH registration dossiers submitted by industry. If at least one company has indicated that the substance classification is affected by impurities or additives, this will be indicated by an informative sentence. It has a CASRN of 9016-87-9. This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing. ... or the UN Global Harmonised System ... Methylene diphenyl diisocyanate . Such notifications are required for hazardous substances, mixtures, or articles, manufactured or imported at over 1 kg per annum. Methylenediphenyl 4,4 -Diisocyanate 97.0 %, TCI America 25G Chemicals:Organic Compounds:Benzenoids:Benzene and substituted derivatives:Diphenylmethanes It may be toxic by … Biocidal Products Committee opinions on active substance approval, National authorisation and mutual recognition, Understanding the Waste Framework Directive, Tools to prepare and submit SCIP notifications, List of substances subject to the POPs Regulation, Draft recommendation for inclusion in the Authorisation List and consultation, Submitted restrictions under consideration, Harmonised classification and labelling targeted consultations, Consultations on ECHA Executive Director’s requests, PACT - Public Activities Coordination Tool, Information on Candidate List substances in articles, Candidate List of substances of very high concern for Authorisation, Registry of restriction intentions until outcome, Registry of SVHC intentions until outcome, Table of harmonised entries in Annex VI to CLP, Occupational exposure limits - Activity list, Harmonised classification and labelling (RAC), Chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Candidate list of substances of very high concern for authorisation, Guidance on the safe use of the substance, PACT - Public activities Co-ordination Tool, Persistence, bioaccumulation and toxicity assessment, RMOA - Regulatory Management Options Analysis, CAD - Chemical Agents Directive,Art. %PDF-1.5 %���� Furthermore, some substances can be found in an article, but with unlikely exposure (e.g. REACH registered substance data was upgraded on 9th November. restriction on "Lead and its compounds"). 4. 6.U.S. Methylene diphenyl diisocyanate; Methylenebis(4-isocyanatobenzene) Methylenebis(4-phenyl isocyanate) Methylenebis(4-phenylene isocyanate) Methylenebis(phenylisocyanate) Methylenebis(phenylisocyanate) (MDI) Methylenebis(p-phenyl isocyanate) Methylenebis(p-phenylene isocyanate) Methylenebisphenylene diisocyanate… Substances for which classification and labelling data have been notified to ECHA by manufacturers or importers. The “polymeric” forms of MDI, which typically consist of 30-70 percent monomeric diphenylmethane diisocyanate and the balance in higher molecular weight fractions (CAS # 5873-54-1) may at times be generically … This substance is used in the following products: adhesives and sealants and coating products. 80 0 obj <> endobj This substance is used for the manufacture of: chemicals. This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 000 per annum. Substances intended to be restricted and entered in Annex XVII to REACH. National Center for Environmental Assessment, Office of Research and Development, … ��#�Y^�7��b�4.F��}��:WI���1w�y�(_W�q2.H�������e�B�r�|�I��|>�Ք^ Gtb�+������Ϸ�9z�W�D����4N��.H�B����+�-�J��t|Rw�����. It does not represent a new labelling, classification or hazard statement, neither reflect other factors that affect the susceptibility of the effects described, such as duration of exposure or substance concentration (e.g. The annexes to this directive provide detailed information about the minimum requirements for all safety and health signs. 0 The molecular formula identifies each type of element by its chemical symbol and identifies the number of atoms of each element found in one discrete molecule of the substance. Tool showing an overview of substances in various key regulatory processes that authorities are working on. The source of the information is mentioned in the introductory sentence of the hazard statements. 0.07 STEL . Harmonisation is based on the substance’s physical, toxicological and eco-toxicological hazard assessment. In that case, the ATP (Adaptation to Technical Progress) number is displayed. According to the annexes to the directive, storage areas and containers containing chemical substances or mixtures that are classified as hazardous according to the CLP Regulation (1272/2008/EC) must be marked and/or labeled. h��WmO�8�+�Z���$Ҫ�[���"�[V��!�ޒS�TIV��f�$�-,P���gƞ�x��.g�0$�J. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed. 6(6), Reg. Methylene-diphenyl-diisocyanate (MDI) 101-68-8 OSHA PEL-TWA 0.02 ppm ACGIH TLV -TWA 0.005 ppm 2 In AFL-CIO v. OSHA 965 F. 2d 962 (11th Cir. InfoCards are updated when new information is available. This section provides an overview of the calculated volume at which the substance is manufactured or imported to the European Economic Area (EU28 + Iceland, Liechtenstein and Norway). If the substance was not covered by the EC Inventory, ECHA attributes a list number in the same format, starting with the numbers 6, 7, 8 or 9. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. Product Number: D0897: Purity / Analysis Method >97.0%(T) Molecular Formula / Molecular Weight: C__1__5H__1__0N__2O__2 = 250.26 : Physical State (20 deg.C) Solid: Storage Temperature: 0-10°C: Store Under Inert Gas: Store under inert gas: Condition to Avoid: Moisture Sensitive,Heat Sensitive: CAS RN: 101-68-8: Reaxys Registry Number… Use … Information on applicable regulatory frameworks is also automatically generated and may not be complete or up to date. The 2016 Emergency Response Guidebook, developed jointly by Transport Canada (TC), the U.S. Department of Transportation (DOT), the Secretariat of Communications and Transport of Mexico (SCT) and with the collaboration of CIQUIME (Centro de Información Química para Emergencias) … Methylenediphenyl diisocyanate (MDI) including the following specific isomers (See group members): Previous consultations on ECHA’s Executive Director Requests to the Committees, Applications for authorisation consultations, Harmonised classification and labelling consultations, ECHA Executive Director’s requests related to the CLH process, Consultation on potential candidates for substitution, Consultation on derogation to the exclusion criteria, ECHA's Executive Director Requests to the Committees, Consultation on a draft recommendation for amendment of Authorisation List entries, Consultations in the authorisation process, Occupational exposure limits - Call for comments and evidence, Occupational exposure limits - Previous calls for comments and evidence, Occupational exposure limits – Consultations on OEL recommendation, Derogations for the protection of cultural heritage, ECHA's current activities on restrictions, ECHA's completed activities on restriction, Information on Candidate List substances in articles table, Information from the Existing Substances Regulation (ESR), PBT/vPvB assessments under the previous EU chemicals legislation, Adopted opinions and previous consultations on applications for authorisation, Adopted opinions on restriction proposals, Mapping exercise – Plastic additives initiative, Occupational exposure limits substance evaluations, List of substances subject to POPs Regulation, Small and Medium-sized Enterprises (SMEs), Practical examples of chemical safety reports. The EC Number is the numerical identifier for substances in the EC Inventory. While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. Stability and reactivity 10.1 Reactivity. For more information, call the ATSDR Information Center at 1-800-232-4636. Methylene diphenyl diisocyanate Prevent eye contact Wash skin: Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and 101-8-8 … … Methylene bisphenyl diisocyanate (MDI) INHALATION LC50-4H RAT 369.00 MG/M3 Polymethylene polyphenyl isocyanate INHALATION LC50-4H RAT 490.00 MG/M3 Methylenediphenyl diisocyanate ORAL LD50 RAT > 7,400 MG/KG INHALATION LC50-4H RAT 0.37 MG/L DERMAL LD50 RABBIT > 6,200.00 MG/KG … ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. fused 4,4’-Methylene Diphenyl Diisocyanate (MDI). 590 Revision Date: 1/8/2019 Version: 10.0 GHS Compliant . This database contains: (1) the list of hazardous substances harmonized for classification and labeling in EU (i.e. This site is not fully supported in Internet Explorer 7 (and earlier versions). Environmental Protection Agency. Resources for Diisocyanates Emergency Response Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. 10.3 Possibility of hazardous reactions. This list contains substances to which pregnant workers and workers who have recently given birth or are breastfeeding may not be exposed. 101-68-8 and 9016-87-9) in Support of Summary Information on the Integrated Risk Information System (IRIS). A flammable liquid.Isocyanates and thioisocyanates, such as DIPHENYLMETHANE-4,4'-DIISOCYANATE, are incompatible with many classes … REACH registration dossiers have greater data requirements (such as supporting studies) than do notifications under CLP. Please note: Precautionary measures and guidance on safe use concern the use and handling of the specific substance as such, not of the presence of the substance in other articles or mixtures. 0.02 . … DOT Environmentally Hazardous Substance, N.O.S. Gilbert, D.C. Allport, January 2001 ... MDI methylene diphenyl diisocyanate technical MDI pure MDI diisocyanatodiphenylmethane crude MDI monomeric MDI methylenediphenylene diisocyanate polymethylene polyphenyl … This list contains biological and chemical agents, in accordance with Art. According to the harmonised classification and labelling (ATP01) approved by the European Union, this substance causes serious eye irritation, is harmful if inhaled, is suspected of causing cancer, may cause damage to organs through prolonged or repeated exposure, causes skin irritation, may cause an allergic skin reaction, may cause allergy or asthma symptoms or breathing difficulties if inhaled and may cause respiratory irritation. 2(b)(i), Directive 98/24/EC on Protection of Workers from Chemical Agent-related Risks, 5 May 1998 (Table 3 of Annex VI to CLP, as amended), EU. Brain injury, 8(3):285–294. 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Physical, Biological and Chemical Agents & Processes and Work, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties. The information is aggregated from the data coming from REACH substance registrations provided by industry. The InfoCard summarises the non-confidential data of a substance held in the databases of the European Chemicals Agency (ECHA). The use information is displayed per substance life cycle stage (consumer use, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites or in manufacturing). While the harmonized list covers many hazardous substances, other ones not listed may also meet the classification criteria in accordance with the CLP. BPR regulation aims to improve the functioning of the biocidal products market in the EU, while ensuring a high level of protection for humans and the environment. The precautionary measures and guidance on safe use are as submitted to ECHA by registrants under the REACH Regulation. Public (risk management) activities co-ordination table. Guidance To help minimize the formation of a dimer, an insoluble white solid that may impact the quality of the product, 4,4’-methylene diphenyl diisocyanate (MDI) is usually stored and transported in drums at temperatures below 41°F (5°C). Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. MDA is consumed mainly as a precursor to 4,4 ́-methylene diphenyl diisocyanate (MDI). Impurities or additives: When a specific critical property is calculated from industry data and where the majority of data submitters have indicated that the property relates to cases containing impurities and/or additives, then the respective critical property icon is modified with an asterisk (*). Identification number: UN 3082 Packing group: III DOT Hazardous Substance(s): Methylene diphenyl diisocyanate, Methylene diphenyl diisocyanate . SAFETY DATA SHEET SDS No. This substance is used in the following products: adhesives and sealants and coating products. However, substance notifications in the InfoCard are aggregated independently of the impurities and additives. Methylenedi-p-phenyl diisocyanate 0.005 ppm TWA 0.005 ppm TWA; 0.05 mg/m3 TWA 75 mg/m3 IDLH 0.02 ppm Ceiling; 0.2 mg/m3 Ceiling Diphenylmethane-2,4'-diisocyanate none listed none listed none listed 2,6-Di-tert-butyl-p-cresol 2 mg/m3 TWA (inhalable fraction and vapor) 10 mg/m3 TWA none listed 2(b)(i) - Hazardous Agents, Cosmetic Products Regulation, Annex II - Prohibited Substances, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Protection of Pregnant and Breastfeeding Workers Directive, Annex I+II, Workplace Signs - minimum requirements & signs on containers and pipes, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Fertiliser Regulation- Annex I, E.3 (chelating and complexing agents), Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). 7 and points 2 and 3 of the Annex to Directive 94/33/EC, to which young persons (under 18 years of age) may not be exposed at the workplace. This substance is used for the manufacture of: machinery and vehicles. Stable under recommended storage conditions. The ‘Substance identity’ section is calculated from substance identification information from all ECHA databases. Substances may be grouped together under a specific regulatory activity for more efficient risk management and legislative processing (e.g. Note that for readability purposes, only the pictograms, signal words and hazard statements referred in more than 5% of the notifications under CLP are displayed. The classifications of the substances listed in the database are based on their harmonized classifications per Table 3 of Annex VI to the CLP Regulation (1272/2008/EC). This information is only displayed if the substance is well–defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. These notifications can be provided by manufacturers, importers and downstream users. The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as being of relevance or importance to human health and/or the environment based on the information provided to the Agency. This substance has been identified as member of the following groups of substances: Welcome to the ECHA website. If generated, an InChI string will also be generated and made available for searching. For a detailed overview on identified uses and environmental releases, please consult the registered substance factsheet. LEL:. More information about the EC Inventory can be found here. binding agent in paints and coatings or adhesives). Note that this list is not exhaustive. Diagnosis of diisocyanate asthma 203 Appendices (David I. Bernstein) 203 Reading217 4 The environment 229 R E Bailey, A Gard, K H den Haan, F Heimbach, D Pemberton, H Tadokoro, M Takatsuki and Y Yakabe A general approach to environmental risk assessment 229 Exposure 233 Sources of exposure 233 … The type of uses and classifications may vary between different submissions to ECHA and for a full understanding it is recommended to consult the source data. MDI and other isocyanates may also cause hypersensitivity pneumonitis, another allergic lung ... Methylene diphenyl diisocyanate (MDI) 0.051 (0.005 ppm) 0.2 (0.02 ppm) 0.005 ppm . 92/85/EEC on Pregnant Workers, 28 November 1992 (updated by table 3 of Annex VI to CLP, 5 Oct 2018), EU. MDI, MMDI, Pure >MDI, rein MDI, 4,4'-MDI, Benzene, 1,1'-methylenebis(4-isocyanato-(9CI)), Benzene, 1,1`-methylenebis(4-isocyanato-(9CI), isocyanaic acid, methylene di-p-phenyleneester(6CI,8CI), Isocyanic acid, methylenedi-p-phenylene ester (6CI, 8CI), Isocyanic acid, methylenedi-p-phenylene ester (6CI,8CI), EC Inventory, C&L Inventory, Restriction list, Substance Evaluation - CoRAP, Registration dossier, Pre-Registration process, Other, CAD - Chemical Agents Directive, Art. Substances may have impurities and additives that lead to different classifications. (3) MDI is the usual abbreviation for monomeric methylene diphenyl diisocyanate, (CAS# 101-68-8). This substance is used in the following areas: formulation of mixtures and/or re-packaging. The CAS number is the substance numerical identifier assigned by the Chemical Abstracts Service, a division of the American Chemical Society, to substances registered in the CAS registry database. It is possible that a harmonisation is introduced through an amendment to the CLP Regulation. The database represents a non-exhaustive list of such substances based on: 1) agents of risk groups 3 and 4 under Directive 2000/54/EC; 2) Table 3 of Annex VI to the CLP Regulation; 3) and Annex I of Directive 2004/37/EC. This section highlights four regulatory activities or outcomes under REACH – Registration, Evaluation, Authorisation and Restriction of Chemicals – Regulation (EC) No 1907/2006: Please note: The identification of relevant regulatory activities and outcomes is done automatically and without manual verification. Workplace Signage: Annexes I and III, Directive 92/58/EEC, last amended by Directive 2014/27/EU, 5 March 2014, EU. Methylene diphenyl diisocyanate (MDI) in commercial form typically exists as a mixture of 4,4'-MDI (monomer) and certain oligomers of MDI (Encyclopedia of Chemical Technology, 1983). An additional source of information is also CHEMTREC, which can be reached at 1-800-424-9300. Action Plan [RIN 2070-ZA15] I. Overview . This Action Plan addresses the use of methylene diphenyl diisocyanate (MDI) and related compounds (See Appendix 1) in products that may result in consumer and general population Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. "�E��z���!9�%��E$�0?�DJrC� This substance is used in the following products: coating products, inks and toners, polymers and cosmetics and personal care products. This information has not been reviewed or verified by ECHA, and may change without prior notice. no data available. 10. This information is only displayed if the substance is well-defined, its identity is not claimed confidential and there is sufficient information available in ECHA’s databases for ECHA’s algorithms to generate a molecular structure. The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. The per substance REACH registration status is being calculated and will be made available as soon as possible. More information about CAS and the CAS registry can be found here. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. %%EOF Methylenediphenyl 4,4'-Diisocyanate . Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) CASRN 101-68-8, 9016-87-9 | DTXSID7025180 This fact sheet answers the most frequently asked health questions (FAQs) about toluene diisocyanate (TDI) and methylenediphenyl diisocyanate (MDI). CHEMTREC operators are available 24 hours a day, seven days a week. endstream endobj 81 0 obj <> endobj 82 0 obj <> endobj 83 0 obj <>stream The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. Hazard statements were adapted to improve readability and may not correspond textually to the hazard statements codes description in the European Union Specific Hazard Statements (EUH) or the. endstream endobj startxref Chemical Agents: Annexes I & II, Dir. The CLP Regulation uses the UN Global Harmonised System (GHS) and European Union Specific Hazard Statements (EUH). This substance is used in the following products: adhesives and sealants and coating products. To confirm if a substance is covered by a specific regulatory action the official publication, e.g. The quality and correctness of the information submitted to ECHA remains the responsibility of the data submitter. Union List of Authorized Substances: Annex I, Plastics Food Contact Regulation 10/2011/EU, as amended by Regulation 2020/1245/EU, 3 September 2020, EU. First-aid measures For readability purpose, only non-confidential use descriptors occurring in more than 5% of total occurrences are displayed. In order to process your orders without delay, we request that you provide the required business documentation to purchase this product. 4,4' Methylene Diphenyl Diisocyanate Reportable Quantity: 5000 lbs When in individual containers of less than the substance RQ, this material ships as non-regulated. In these cases, Infocards may not identify all substances in the group.Therefore it does not represent official and legally–binding information. Gas concentrations are in percent by volume. disodium tetraborate EC no. the electronic edition of the Official Journal of the European Union should be consulted. MDA is treated with phosgene to give MDI. 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